מאמרים שפורסמו

2025

ProtoMol: enhancing molecular property prediction via prototype-guided multimodal learning

Wang Y., Zhang K., Huang J., Yin N., Liu S. & Segal E. (2025) Briefings in Bioinformatics. 26, 6, bbaf629.

  08 December 2025

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Artificial intelligence in metabolic research

Holst J. J., Scheele C., Scherer P. E., Jia W., Segal E., Slavov N., Loos R. J. F., Vahedi G., Sun L., Babu M. M., McCradden M. D. & Jacobs P. G. (2025) Nature Metabolism. 7, 11, p. 2183-2186

02 October 2025

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Fibro predict a machine learning risk score for advanced liver fibrosis in the general population using Israeli electronic health records

Kalka I. N., Hazzan R., Yacovzada N. S., Igbaria S., Segal E., Weinberger A. & Neeman Z. (2025) Scientific Reports. 15, 32035.

01 September 2025

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Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes

Carletti M., Pandit J., Gadaleta M., Chiang D., Delgado F., Quartuccio K., Fernandez B., Raygoza Garay J. A., Torkamani A., Miotto R., Rossman H., Berk B., Baca-Motes K., Kheterpal V., Segal E., Topol E. J., Ramos E. & Quer G. (2025) Nature Medicine. 31, 9, p. 3121-3127

31 July 2025

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Crohns disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset

Bourgonje A. R., Andreu-Sánchez S., Gacesa R., Innocenti G., Kalka I. N., Klompus S., Leviatan S., Schlesinger Y., Krongauz D., Weinberger A., Van Der Vegt B., Fu J., Segal E., Zhernakova A., Vogl T. & Weersma R. K. (2025) Gut. 74, 12, p. 1977-1988 334362.

2 July 2025

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Deep phenotyping of health-disease continuum in the Human Phenotype Project

Reicher L., Shilo S., Godneva A., Lutsker G., Zahavi L., Shoer S., Krongauz D., Rein M., Kohn S., Segev T., Schlesinger Y., Barak D., Levine Z., Keshet A., Shaulitch R., Lotan-Pompan M., Elkan M., Talmor-Barkan Y., Aviv Y., Dadiani M., Tsodyks Y., Gal-Yam E. N., Leibovitzh H., Werner L., Tzadok R., Maharshak N., Koga S., Glick-Gorman Y., Stossel C., Raitses-Gurevich M., Golan T., Dhir R., Reisner Y., Weinberger A., Rossman H., Song L., Xing E. P. & Segal E. (2025) Nature Medicine. 31, 9, p. 3191-3203

15 July 2025

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Generative AI enables medical image segmentation in ultra low-data regimes

Zhang L., Jindal B., Alaa A., Weinreb R., Wilson D., Segal E., Zou J. & Xie P. (2025) Nature Communications. 16, 6486.

14 July 2025

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Baseline Characteristics of Weight-Loss Success in a Personalized Nutrition Intervention: A Secondary Analysis

Popp C. J., Wang C., Berube L., Curran M., Hu L., Pompeii M. L., Barua S., Li H., St-Jules D. E., Schoenthaler A., Segal E., Bergman M. & Sevick M. A. (2025) Nutrients. 17, 13, 2178.

30 June 2025

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Characterizing the metabolome of children with growth hormone deficiency

Shilo S., Keshet A., Halloun R., Bar N., Cohen M., Gal S., Oren M., Glantz-Gashai Y., Malitsky S., Itkin M., Lotan-Pompan M., Godneva A., Weinberger A., Tiosano D. & Segal E. (2025) Journal of Pediatric Endocrinology and Metabolism. 38, 8, p. 815-823

May 26, 2025

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Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimers Disease

Villacampa N., Sarlus H., Martorell P., Bhalla K., Gomez-Castro S., Vieira-Saecker A., Slutzkin I., Händler K., Venegas C., McManus R., Ulas T., Beyer M., Segal E. & Heneka M. T. (2025) ASN Neuro. 17, 1, 2506406.

19 May 2025

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Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

Smith B. J., Zhao C., Dubinkina V., Jin X., Zahavi L., Shoer S., Moltzau-Anderson J., Segal E. & Pollard K. S. (2025) Genome Research. 35, 5, p. 1247-1260

March 6, 2025

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Precision nutrition for cardiometabolic diseases

Guasch-Ferré M., Wittenbecher C., Palmnäs M., Ben-Yacov O., Blaak E. E., Dahm C. C., Fall T., Heitmann B. L., Licht T. R., Löf M., Loos R., Patel C. J., Quarta C., Redman L. M., Segal E., Segata N., Snyder M., Sun Q., Tobias D. K., Hu F. B., Franks P. W., Landberg R., Sargent J. L. & Merino J. (2025) Nature Medicine. 31, 5, p. 1444-1453

30 April 2025

Development of antibiotic resistome in premature infants

Keshet A., Hochwald O., Lavon A., Borenstein-Levin L., Shoer S., Godneva A., Glantz-Gashai Y., Cohen-Dolev N., Timstut F., Lotan-Pompan M., Solt I., Weinberger A., Segal E. & Shilo S. (2025) Cell Reports. 44, 4, 115515.

22 April 2025

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Clinical translation of microbiome research

Gilbert J. A., Azad M. B., Bäckhed F., Blaser M. J., Byndloss M., Chiu C. Y., Chu H., Dugas L. R., Elinav E., Gibbons S. M., Gilbert K. E., Henn M. R., Ishaq S. L., Ley R. E., Lynch S. V., Segal E., Spector T. D., Strandwitz P., Suez J., Tropini C., Whiteson K. & Knight R. (2025) Nature Medicine. 31, 4, p. 1099-1113

11 April 2025

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Phenome-wide associations of sleep characteristics in the Human Phenotype Project

Kohn S., Diament A., Godneva A., Dhir R., Weinberger A., Reisner Y., Rossman H. & Segal E. (2025) Nature Medicine. 31, 3, p. 1026-1037 4881.

27 January 2025

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International consensus statement on microbiome testing in clinical practice

Porcari S., Mullish B. H., Asnicar F., Ng S. C., Zhao L., Hansen R., O'Toole P. W., Raes J., Hold G., Putignani L., Hvas C. L., Zeller G., Koren O., Tun H., Valles-Colomer M., Collado M. C., Fischer M., Allegretti J., Iqbal T., Chassaing B., Keller J., Baunwall S. M., Abreu M., Barbara G., Zhang F., Ponziani F. R., Costello S. P., Paramsothy S., Kao D., Kelly C., Kupcinskas J., Youngster I., Franceschi F., Khanna S., Vehreschild M., Link A., De Maio F., Pasolli E., Miguez A. B., Brigidi P., Posteraro B., Scaldaferri F., Stojanovic M. R., Megraud F., Malfertheiner P., Masucci L., Arumugam M., Kaakoush N., Segal E., Bajaj J., Leong R., Cryan J., Weersma R. K., Knight R., Guarner F., Shanahan F., Cani P. D., Elinav E., Sanguinetti M., de Vos W. M., El-Omar E., Dorè J., Marchesi J., Tilg H., Sokol H., Segata N., Cammarota G., Gasbarrini A. & Ianiro G. (2025) The Lancet Gastroenterology and Hepatology. 10, 2, p. 154-167

February 2025

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2024

Sex-specific dietary habits and their association with weight change in healthy adults

Rein M., Elkan M., Godneva A., Dolev N. C. & Segal E. (2024) BMC Medicine. 22, 5

06/11/2024

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Phenome-wide associations of human aging uncover sex-specific dynamics

Reicher L., Bar N., Godneva A., Reisner Y., Zahavi L., Shahaf N., Dhir R., Weinberger A. & Segal E. (2024) Nature Aging. 4, 11, p. 1643-1655

05/11/2024

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Identification of gut microbiome features associated with host metabolic health in a large population-based cohort

Keshet A. & Segal E. (2024) Nature Communications. 15, 9358

29/10/2024

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Pangenomes of human gut microbiota uncover links between genetic diversity and stress response

Reicher L., Bar N., Godneva A., Reisner Y., Zahavi L., Shahaf N., Dhir R., Weinberger A. & Segal E. (2024) Nature Aging. 4, 11, p. 1643-1655

09/10/2024

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Diabetes Telemedicine Mediterranean Diet (DiaTeleMed) Study: study protocol for a fully remote randomized clinical trial evaluating personalized dietary management in individuals with type 2 diabetes

Berube L. T., Popp C. J., Curran M., Hu L., Pompeii M. L., Barua S., Bernstein E., Salcedo V., Li H., St-Jules D. E., Segal E., Bergman M., Williams N. J. & Sevick M. A. (2024) Trials. 25, 506

25/07/2024

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Continuous glucose monitoring and intrapersonal variability in fasting glucose

Shilo S., Keshet A., Rossman H., Godneva A., Talmor-Barkan Y., Aviv Y. & Segal E. (2024) Nature Medicine. 30, 5, p. 1424-1431

08/04/2024

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Competitive fungal commensalism mitigates candidiasis pathology

Sekeresova Kralova J., Donic C., Dassa B., Livyatan I., Jansen P. M., Ben-Dor S., Fidel L., Trzebanski S., Narunsky-Haziza L., Asraf O., Brenner O., Dafni H., Jona G., Boura-Halfon S., Stettner N., Segal E., Brunke S., Pilpel Y., Straussman R., Zeevi D., Bacher P., Hube B., Shlezinger N. & Jung S. (2024) Journal of Experimental Medicine. 221, 5, e20231686.

18/03/2024

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Quantification of beta cell carrying capacity in prediabetes

Woller A., Tamir Y., Bar A., Mayo A., Rein M., Godneva A., Cohen N. M., Segal E., Toledano Y., Shilo S., Gonze D. & Alon U. (2024) BioRxiv.

02/03/2024

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2023

Med

Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project

Zachary Levine, Iris Kalka, Dmitry Kolobkov, Tom sharon, Adina Weinberger, Eran Segal

12/28/2023

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MACHINE LEARNING FOR HEALTH (ML4H) SYMPOSIUM 2023

A Multimodal Dataset of 21,412 Recorded Nights for Sleep and Respiratory Research

Alon Diament, Maria Gorodetski, Adam Jankelow, Ayya Keshet, Tal Shor, Daphna Weissglas-Volkov, Hagai Rossman, Eran Segal

11/15/2023

2022

SCIENCE ADVANCES

Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients

Thomas Vogl, Iris N Kalka, Shelley Klompus, Sigal Leviatan, Adina Weinberger, Eran Segal

09/23/2022

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PLOS ONE

An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents

Daphna Rothschild, Sigal Leviatan, Ariel Hanemann, Yossi Cohen, Omer Weissbrod, Eran Segal 

03/24/2022

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NATURE MEDICINE

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

Yeela Talmor-Barkan, Noam Bar, Aviv A Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal

02/17/2022

2021

IMMUNITY, INFLAMMATION AND DISEASE

Clinical efficacy of fecal microbial transplantationtreatment in adults with moderate‐to‐severe atopicdermatitis

Mashiah J, Karady T, Fliss-Isakov N, Sprecher E, Slodownik D, Artzi O, Samuelov L, Ellenbogen E, Godneva A, E. Segal, Maharshak N.

12/20/2021

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DIABETES CARE

Personalized Postprandial Glucose Response-Targeting Diet Versus Mediterranean Diet for Glycemic Control in Prediabetes

Ben-Yacov O, Godneva A, Rein M, Shilo S, Kolobkov D, Koren N, Cohen Dolev N, Travinsky Shmul T, Wolf BC, Kosower N, Sagiv K, Lotan-Pompan M, Zmora N, Weinberger A, Elinav E, E. Segal

07/23/2021

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NATURE MEDICINE

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

Vogl T, Klompus S, Leviatan S, Kalka IN, Weinberger A, Wijmenga C, Fu J, Zhernakova A, Weersma RK, E. Segal

07/19/2021

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EUROPEAN JOURNAL EPIDEMIOLOGY

Cohort profile: 10K - a large-scale prospective longitudinal study in Israel

7. S. Shilo, N. Bar, A. Keshet, Y. Talmor-Barkan, H. Rossman, A. Godneva, Y. Aviv, Y. Edlitz, L. Reicher, D. Kolobkov, BC. Wolf, M. Lotan-Pompan, K. Levi, O. Cohen, H. Saranga, A. Weinberger, E. Segal

02/23/2021

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CELL REPORTS MEDICINE

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis

D. Zeevi, T. Korem, A. Godneva, N. Bar, A. Kurilshikov, M. Lotan-Pompan, A. Weinberger, J. Fu, C. Wijmenga, A. Zhernakova, E. Segal

04/20/2021

2020

NATURE

A reference map of potential determinants for the human serum metabolome

N. Bar, T. Korem, O. Weissbrod, D. Zeevi, D. Rothschild, S. Leviatan, N. Kosower, M. Lotan-Pompan, A. Weinberger, CI. Le Roy, C. Menni, A. Visconti, M. Falchi, TD. Spector; IMI DIRECT consortium, J. Adamski, PW. Franks, O. Pedersen, E. Segal

12/03/2020

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NATURE

Rich data sets could end costly drug discovery

E. Segal

02/2020

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NATURE MEDICINE

Axes of a revolution: challenges and promises of big data in healthcare

S. Shilo, H. Rossman, E. Segal

01/13/2020

2019

NATURE

Potential roles of gut microbiome and metabolites in modulating ALS in mice

12. E. Blacher, S. Bashiardes, H. Shapiro,D. Rothschild, U. Mor1, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. Ben-Zeev Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, L. Arike, M. Johansson, G.C. Hansson, M. Gotkine, E. Segal*, E. Elinav*

07/22/2019

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NATURE

Sub-genomic variation in the gut microbiome associates with host metabolic health

D. Zeevi, T. Korem, A. Godneva, N. Bar, A. Kurilshikov, M. Lotan-Pompan, A. Weinberger, J. Fu, C. Wijmenga, A. Zhernakova, E. Segal

03/27/2019

2018

CELL

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Jotham Suez, Niv Zmora, Gili Zilberman-Schapira, Uria Mor, Mally Dori-Bachash, Stavros Bashiardes, Maya Zur, Dana Regev-Lehavi, Rotem Ben-Zeev Brik, Sara Federici, Max Horn, Yotam Cohen, Andreas E Moor, David Zeevi, Tal Korem, Eran Kotler, Alon Harmelin, Shalev Itzkovitz, Nitsan Maharshak, Oren Shibolet, Meirav Pevsner-Fischer, Hagit Shapiro, Itai Sharon, Zamir Halpern, Eran Segal, Eran Elinav

09/06/2018

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CELL

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

N. Zmora, G. Zilberman-Schapira, J. Suez, U. Mor, M. Dori-Bachash, S. Bashiardes, E. Kotler, M. Zur, D. Regev-Lehavi, R. Ben-Zeev Brik, S. Federici, Y. Cohen, R. Linevsky, D. Rothschild, AE. Moor, S. Ben-Moshe, A. Harmelin, A. Harmelin, S. Itzkovitz, N. Maharshak, O. Shibolet, H. Shapiro, M. Pevsner-Fischer, I. Sharon, Z. Halpern, E. Segal*, E. Elinav*

09/06/2018

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NATURE

Environment dominates over host genetics in shaping human gut microbiota

D. Rothschild, O. Weissbrod, E. Barkan, A. Kurilshikov, T. Korem, D. Zeevi, PI. Costea, A. Godneva, IN. Kalka, N. Bar, S. Shilo, D. Lador, AV. Vila, N. Zmora, M. Pevsner-Fischer, D. Israeli, N. Kosower, G. Malka, BC. Wolf, T. Avnit-Sagi, M. Lotan-Pompan, A. Weinberger, Z. Halpern, S. Carmi, J. Fu, Lifelines cohort study, C. Wijmenga, A. Zhernakova, E. Elinav, E. Segal

03/08/2018

2016

NATURE

Persistent microbiome alterations modulate the rate of post-dieting weight regain

C.A. Thaiss, S. Itav, D. Rothschild, M. Meijer, C. Moresi, M. Levy, L. Dohnalová, S. Rozin, Y. Kuperman, I. Biton, A. Harmelin, H. Shapiro, E. Segal*, E. Elinav*

12/22/2016

2015

CELL

Personalized Nutrition by Prediction of Glycemic Responses

D. Zeevi, T. Korem, D. Rothschild, A. Weinberger, N. Zmora, D. Israeli 6, O. Ben-Yacov, D. Lador, T. Avnit-Sagi, M. Lotan-Pompan, J. Suez, J. Ali Mahdi, E. Matot, G. Malka, N. Kosower, M. Rein, G. Zilberman, L. Dohnalova, M. Pevsner-Fischer, R. Bikovsky, Z. Halpern, E. Elinav, E. Segal

11/19/2015

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SCIENCE

Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples

T. Korem, D. Zeevi, J. Suez, A. Weinberger, T. Avnit-Sagi, M. Pompan-Lotan, E. Matot, G. Jona, A. Harmelin, N. Cohen, A. Sirota-Madi, C.A. Thaiss, M. Pevsner-Fischer, R. Sorek, R. Xavier, E. Elinav, E. Segal

09/04/2015

2014

NATURE

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

J. Suez, T. Korem, D. Zeevi, G. Zilberman-Schapira, C.A. Thaiss, O. Maza, D. Israeli, N. Zmora, S. Gilad, A. Weinberger, Y. Kuperman, A. Harmelin, I. Kolodkin-Gal, H. Shapiro, Z. Halpern, E. Segal*, E. Elinav*

09/17/2014